The .pod file format has been updated many times. If you try to load a new .pod file on an older Podium release you may get an error message saying that the file format is from a newer Podium version, but you’ll always be able to load older .pod files in newer Podium releases.
In the future there may be updates to the way hardware devices are handled in Podium, but I don’t see a need to change something that would corrupt older hardware device setups.