This problem with Xpand!2 VSTi and Podium 3.2.5 (x64) occours only with this Hardware configuration:
Intel i7-4770 CPU, 8 Cores, 3.4GHz
8 GB Ram
Windows 10 (x64)
ASIO4ALL 2.12
i have tested Xpand!2 VSTi with other DAWs (REAPER 5, Cubase 8) with this hardware configuration and it works!
On my old Hardware Xpand!2 VSTi works with Podium 3.2.5 (x64)
Intel E8400 CPU, 2 Cores, 3 GHz
4 GB Ram
Windows 10 (x64)
ASIO4ALL 2.12