Hi, thanks for the reply. I have figured out when it loses the settings.
If I save the project and the MIDI interface is not plugged in, then Podium marks the relevant devices as unavailable in the saved file (which they are unavailable).
The problem is when you plug the MIDI interface back in, then open Podium, they are still left marked as unavailable (even though they are now available).
This seems to happen in any project and with any interface that is removable.